Welcome to the PediPro video series, where we explore the complexities of pediatric healthcare through expert case studies and clinical insights. In this 4th case study, Prof (Dr.) Bharat J Parmar, Professor and Head of the Pediatric Department at Zydus Medical College and Hospital, presents the intricate management of Sickle Cell Disease (SCD) in a young patient. The case, “Clinical Approaches: Sickle Cell Anemia,” highlights the challenges of SCD's complex pathophysiology and the importance of early diagnosis, innovative therapeutic strategies, and comprehensive patient care. Prof (Dr.) Parmar discusses advanced treatment options, such as hydroxyurea therapy and targeted interventions, while addressing the ongoing challenges in SCD management. Tune in to learn more about evolving strategies and their role in improving outcomes for patients with this genetic condition.